Grupo de Medicina Xenómica

Publications

Roig B, Moyano S, Martorell L, Costas J, Vilella E. The Discoidin domain receptor 1 gene has a functional A2RE sequence. J Neurochem 2011, in press.

Carrera N, Arrojo M, Sanjuán J, Ramos-Ríos R, Paz E, Suárez-Rama JJ, Páramo M, Agra S, Brenlla J, Martínez S, Rivero O, Collier DA, Palotie A, Cichon S, Nöthen MM, Rietschel M, Rujescu D, Stefansson H, Steinberg S, Sigurdsson E, St Clair, D, Tosato S, Werge T, Stefansson K, González JC, Valero J, Gutiérrez-Zotes A, Labad A, Martorell L, Vilella E, Carracedo A, Costas J. Association study of non-synonymous single nucleotide polymorphisms in schizophrenia. Biol Psychiatry 2011, in press.

Steinberg S, de Jong S; Irish Schizophrenia Genomics Consortium, Andreassen OA, Werge T, Børglum AD, Mors O, Mortensen PB, Gustafsson O, Costas J, Pietiläinen OP, Demontis D, Papiol S, Huttenlocher J, Mattheisen M, Breuer R, Vassos E, Giegling I, Fraser G, Walker N, Tuulio-Henriksson A, Suvisaari J, Lönnqvist J, Paunio T, Agartz I, Melle I, Djurovic S, Strengman E; GROUP, Jürgens G, Glenthøj B, Terenius L, Hougaard DM, Orntoft T, Wiuf C, Didriksen M, Hollegaard MV, Nordentoft M, van Winkel R, Kenis G, Abramova L, Kaleda V, Arrojo M, Sanjuán J, Arango C, Sperling S, Rossner M, Ribolsi M, Magni V, Siracusano A, Christiansen C, Kiemeney LA, Veldink J, van den Berg L, Ingason A, Muglia P, Murray R, Nöthen MM, Sigurdsson E, Petursson H, Thorsteinsdottir U, Kong A, Rubino IA, De Hert M, Réthelyi JM, Bitter I, Jönsson EG, Golimbet V, Carracedo A, Ehrenreich H, Craddock N, Owen MJ, O'Donovan MC; Wellcome Trust Case Control Consortium, Ruggeri M, Tosato S, Peltonen L, Ophoff RA, Collier DA, St Clair D, Rietschel M, Cichon S, Stefansson H, Rujescu D, Stefansson K. Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia. Hum Mol Genet. 2011, 20:476-81.

Costas J, Sanjuán J, Ramos-Ríos R, Paz E, Agra S, Tolosa A, Páramo M, Brenlla J, Arrojo M. Interaction between COMT haplotypes and cannabis in schizophrenia: a case-only study in two samples from Spain. Schizophrenia Res 2011, 127(1-3):22-27.

Tubio JMC, Tojo M, Bassaganyas L, Escaramis G, Sharakhov I, Sharakhova M, Tornador C, Unger MF, Naveira H, Costas J, Besansky NJ. Evolutionary Dynamics of the Ty3/gypsy LTR Retrotransposons in the Genome of Anopheles gambiae. PLOS One 2011, 6(1):e16328.

Costas J, Sanjuán J, Ramos-Ríos R, Paz E, Agra S, Ivorra JL, Páramo M, Brenlla J, Arrojo M. Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: New data and meta-analysis. J Psychiatr Res. 2011, 45:7-14.

Gilabert-Juan J, Ivorra JL, Tolosa A, Gratacòs M, Costas J, Sanjuán J, Moltó MD. Potential involvement of serotonin receptor genes with age of onset and gender in schizophrenia: A preliminary study in a Spanish sample. Psychiatry Res. 2011; 186:153-4.

Arensburger P, Megy K, Waterhouse RM, Abrudan J, Amedeo P, Antelo B, Bartholomay L, Bidwell S, Caler E, Camara F, Campbell CL, Campbell KS, Casola C, Castro MT, Chandramouliswaran I, Chapman SB, Christley S, Costas J, Eisenstadt E, Feschotte C, Fraser-Liggett C, Guigo R, Haas B, Hammond M, Hansson BS, Hemingway J, Hill SR, Howarth C, Ignell R, Kennedy RC, Kodira CD, Lobo NF, Mao C, Mayhew G, Michel K, Mori A, Liu N, Naveira H, Nene V, Nguyen N, Pearson MD, Pritham EJ, Puiu D, Qi Y, Ranson H, Ribeiro JM, Roberston HM, Severson DW, Shumway M, Stanke M, Strausberg RL, Sun C, Sutton G, Tu ZJ, Tubio JM, Unger MF, Vanlandingham DL, Vilella AJ, White O, White JR, Wondji CS, Wortman J, Zdobnov EM, Birren B, Christensen BM, Collins FH, Cornel A, Dimopoulos G, Hannick LI, Higgs S, Lanzaro GC, Lawson D, Lee NH, Muskavitch MA, Raikhel AS, Atkinson PW. Sequencing of Culex quinquefasciatus establishes a platform for mosquito comparative genomics. Science. 2010, 330(6000):86-8.

Costas J, Gratacòs M, Escaramís G, Martín-Santos R, de Diego Y, Baca-García E, Canellas F, Estivill X, Guillamat R, Guitart M, Gutiérrez-Zotes A, García-Esteve L, Mayoral F, Moltó MD, Phillips C, Roca M, Carracedo A, Vilella E, Sanjuán J. Association study of 44 candidate genes with depressive and anxiety symptoms in post-partum women. J Psychiatr Res. 2010 Aug; 44 (11) :717-24.

Carrera N, Arrojo M, Paz E, Ramos-Ríos R, Agra S, Páramo M, Brenlla J, Costas J. Testing the antagonistic pleiotropy model of schizophrenia susceptibility by analysis of DAOA, PPP1R1B, and APOL1 genes. Psychiatry Res. 2010, 179:126-9.

Baca-Garcia E, Vaquero-Lorenzo C, Perez-Rodriguez MM, Gratacòs M, Bayés M, Santiago-Mozos R, Leiva-Murillo JM, de Prado-Cumplido M, Artes-Rodriguez A, Ceverino A, Diaz-Sastre C, Fernandez-Navarro P, Costas J, Fernandez-Piqueras J, Diaz-Hernandez M, de Leon J, Baca-Baldomero E, Saiz-Ruiz J, Mann JJ, Parsey RV, Carracedo A, Estivill X, Oquendo MA. Nucleotide variation in central nervous system genes among male suicide attempters. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5; 153B (1) :208-13.

González-Díaz H, Pérez-Montoto LG, Duardo-Sanchez A, Paniagua E, Vázquez-Prieto S, Vilas R, Dea-Ayuela MA, Bolas-Fernández F, Munteanu CR, Dorado J, Costas J, Ubeira FM. Generalized lattice graphs for 2D-visualization of biological information. J Theor Biol. 2009 Nov 7; 261 (1) :136-47.

Gratacòs M*, Costas J*, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, Psychiatric Genetics Network Group. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. Am J Med Genet B Neuropsychiatr Genet. 2009 Sep 5; 150B (6) :808-16. 

*First co-authors

Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietiläinen OP, Mors O, Mortensen PB, Sigurdsson E, Gustafsson O, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Suvisaari J, Lonnqvist J, Paunio T, Børglum AD, Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Böttcher Y, Olesen J, Breuer R, Möller HJ, Giegling I, Rasmussen HB, Timm S, Mattheisen M, Bitter I, Réthelyi JM, Magnusdottir BB, Sigmundsson T, Olason P, Masson G, Gulcher JR, Haraldsson M, Fossdal R, Thorgeirsson TE, Thorsteinsdottir U, Ruggeri M, Tosato S, Franke B, Strengman E, Kiemeney LA, Genetic Risk and Outcome in Psychosis (GROUP), Melle I, Djurovic S, Abramova L, Kaleda V, Sanjuan J, de Frutos R, Bramon E, Vassos E, Fraser G, Ettinger U, Picchioni M, Walker N, Toulopoulou T, Need AC, Ge D, Yoon JL, Shianna KV, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Carracedo A, Arango C, Costas J, Jönsson EG, Terenius L, Agartz I, Petursson H, Nöthen MM, Rietschel M, Matthews PM, Muglia P, Peltonen L, St Clair D, Goldstein DB, Stefansson K, Collier DA. Common variants conferring risk of schizophrenia. Nature. 2009 Aug 6; 460 (7256) :744-7.

Carrera N, Sanjuán J, Moltó MD, Carracedo A, Costas J. Recent adaptive selection at MAOB and ancestral susceptibility to schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 5; 150B (3) :369-74.

Dieguez-Gonzalez R, Akar S, Calaza M, Perez-Pampin E, Costas J, Torres M, Vicario JL, Velloso ML, Navarro F, Narvaez J, Joven B, Herrero-Beaumont G, Gonzalez-Alvaro I, Fernandez-Gutierrez B, de la Serna AR, Carreño L, Lopez-Longo J, Caliz R, Collado-Escobar MD, Blanco FJ, Fernandez-Lopez C, Balsa A, Pascual-Salcedo D, Gomez-Reino JJ, Gonzalez A. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. Ann Rheum Dis. 2009 Apr; 68 (4) :579-83.

Costas J, Carrera N, Domínguez E, Vilella E, Martorell L, Valero J, Gutiérrez-Zotes A, Labad A, Carracedo A. A common haplotype of DRD3 affected by recent positive selection is associated with protection from schizophrenia. Hum Genet. 2009 Jan; 124 (6) :607-13.

Sanjuan J, Martin-Santos R, Garcia-Esteve L, Carot JM, Guillamat R, Gutierrez-Zotes A, Gornemann I, Canellas F, Baca-Garcia E, Jover M, Navines R, Valles V, Vilella E, de Diego Y, Castro JA, Ivorra JL, Gelabert E, Guitart M, Labad A, Mayoral F, Roca M, Gratacos M, Costas J, van Os J, de Frutos R. Mood changes after delivery: role of the serotonin transporter gene. Br J Psychiatry. 2008; 193 (5) :383-8.

Martorell L, Costas J, Valero J, Gutierrez-Zotes A, Phillips C, Torres M, Brunet A, Garrido G, Carracedo A, Guillamat R, Vallès V, Guitart M, Labad A, Vilella E. Analyses of variants located in estrogen metabolism genes (ESR1, ESR2, COMT and APOE) and schizophrenia. Schizophr Res. 2008; 100 (1-3) :308-15.

Vilella E, Costas J, Sanjuan J, Guitart M, De Diego Y, Carracedo A, Martorell L, Valero J, Labad A, De Frutos R, Nájera C, Moltó MD, Toirac I, Guillamat R, Brunet A, Vallès V, Pérez L, Leon M, de Fonseca FR, Phillips C, Torres M. Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction. J Psychiatr Res. 2008; 42 :278-8.

Tolosa A, Sanjuán J, Leal C, Costas J, Moltó MD, de Frutos R. Rapid evolving RNA gene HAR1A and schizophrenia. Schizophr Res. 2008; 99 (1-3) :370-2.

Roig B, Virgos C, Franco N, Martorell L, Valero J, Costas J, Carracedo A, Labad A, Vilella E. The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia. Mol Psychiatry. 2007 Sep; 12 (9) :833-41.

Nene V, Wortman JR, Lawson D, Haas B, Kodira C, Tu ZJ, Loftus B, Xi Z, Megy K, Grabherr M, Ren Q, Zdobnov EM, Lobo NF, Campbell KS, Brown SE, Bonaldo MF, Zhu J, Sinkins SP, Hogenkamp DG, Amedeo P, Arensburger P, Atkinson PW, Bidwell S, Biedler J, Birney E, Bruggner RV, Costas J, Coy MR, Crabtree J, Crawford M, Debruyn B, Decaprio D, Eiglmeier K, Eisenstadt E, El-Dorry H, Gelbart WM, Gomes SL, Hammond M, Hannick LI, Hogan JR, Holmes MH, Jaffe D, Johnston JS, Kennedy RC, Koo H, Kravitz S, Kriventseva EV, Kulp D, Labutti K, Lee E, Li S, Lovin DD, Mao C, Mauceli E, Menck CF, Miller JR, Montgomery P, Mori A, Nascimento AL, Naveira HF, Nusbaum C, O'leary S, Orvis J, Pertea M, Quesneville H, Reidenbach KR, Rogers YH, Roth CW, Schneider JR, Schatz M, Shumway M, Stanke M, Stinson EO, Tubio JM, Vanzee JP, Verjovski-Almeida S, Werner D, White O, Wyder S, Zeng Q, Zhao Q, Zhao Y, Hill CA, Raikhel AS, Soares MB, Knudson DL, Lee NH, Galagan J, Salzberg SL, Paulsen IT, Dimopoulos G, Collins FH, Birren B, Fraser-Liggett CM, Severson DW. Genome sequence of Aedes aegypti, a major arbovirus vector. Science. 2007 Jun 22; 316 (5832) :1718-23.

Domínguez E, Loza MI, Padín F, Gesteira A, Paz E, Páramo M, Brenlla J, Pumar E, Iglesias F, Cibeira A, Castro M, Caruncho H, Carracedo A, Costas J. Extensive linkage disequilibrium mapping at HTR2A and DRD3 for schizophrenia susceptibility genes in the Galician population. Schizophr Res. 2007 Feb; 90 (1-3) :123-9.

Costas J, Perez-Pampin E, Ferreiros-Vidal I, Torres M, Phillips C, Vicario JL, Pablos JL, Carracedo A, Gomez-Reino JJ, Gonzalez A. SUMO4 and MAP3K7IP2 single nucleotide polymorphisms and susceptibility to rheumatoid arthritis. J Rheumatol. 2006 Jun; 33 (6) :1048-51.

Loidi L, Quinteiro C, Parajes S, Barreiro J, Lestón DG, Cabezas-Agrícola JM, Sueiro AM, Araujo-Vilar D, Catro-Feijóo L, Costas J, Pombo M, Domínguez F. High variability in CYP21A2 mutated alleles in Spanish 21-hydroxylase deficiency patients, six novel mutations and a founder effect. Clin Endocrinol (Oxf). 2006 Mar; 64 (3) :330-6.

Costas J. Estudios genéticos de asociación de enfermedades multifactoriales complejas. Neurol Supl 2005;1(3):44-50.

Costas J, Torres M, Cristobo I, Phillips C, Carracedo A. Relative efficiency of the linkage disequilibrium mapping approach in detecting candidate genes for schizophrenia in different European populations. Genomics. 2005 Sep; 86 (3) :280-6.

López-Sánchez P, Costas JC, Naveira HF. Paleogenomic record of the extinction of human endogenous retrovirus ERV9. J Virol. 2005 Jun; 79 (11) :6997-7004.

Costas J, Salas A, Phillips C, Carracedo A. Human genome-wide screen of haplotype-like blocks of reduced diversity. Gene. 2005 Apr 11; 349:219-25.

Tubío JM, Naveira H, Costas J. Structural and evolutionary analyses of the Ty3/gypsy group of LTR retrotransposons in the genome of Anopheles gambiae. Mol Biol Evol. 2005 Jan; 22 (1) :29-39. PubMed PMID:15356275.

Costas J, Pereira PS, Vieira CP, Pinho S, Vieira J, Casares F. Dynamics and function of intron sequences of the wingless gene during the evolution of the Drosophila genus. Evol Dev. 2004 Sep-Oct; 6 (5) :325-35.

Tubío JM, Costas JC, Naveira HF. Evolution of the mdg1 lineage of the Ty3/gypsy group of LTR retrotransposons in Anopheles gambiae. Gene. 2004 Apr 14; 330:123-31.

Costas J, Vieira CP, Casares F, Vieira J. Genomic characterization of a repetitive motif strongly associated with developmental genes in Drosophila. BMC Genomics. 2003 Dec 16; 4 (1) :52. PubMed PMID:14675495;

Costas J, Casares F, Vieira J. Turnover of binding sites for transcription factors involved in early Drosophila development. Gene. 2003 May 22; 310:215-20. PubMed PMID:12801649.

Costas J. Molecular characterization of the recent intragenomic spread of the murine endogenous retrovirus MuERV-L. J Mol Evol. 2003 Feb; 56 (2) :181-6.

Costas J. Characterization of the intragenomic spread of the human endogenous retrovirus family HERV-W. Mol Biol Evol. 2002 Apr; 19 (4) :526-33.

Costas J. Evolutionary dynamics of the human endogenous retrovirus family HERV-K inferred from full-length proviral genomes. J Mol Evol. 2001 Sep; 53 (3) :237-43.

Costas J, Valadé E, Naveira H. Structural features of the mdg1 lineage of the Ty3/gypsy group of LTR retrotransposons inferred from the phylogenetic analyses of its open reading frames. J Mol Evol. 2001 Sep; 53 (3) :165-71.

Vega A, Salas A, Costas J, Barros F, Carracedo A. Length variability and interspersion patterns of the HRAS1 minisatellite: a new approach for the reconstruction of human population relationships. Ann Hum Genet. 2001 Jul; 65 (Pt 4) :351-61.

Costas J, Valadé E, Naveira H. Amplification and phylogenetic relationships of a subfamily of blood, a retrotransposable element of Drosophila. J Mol Evol. 2001 Apr; 52 (4) :342-50.

Costas J, Naveira H. Evolutionary history of the human endogenous retrovirus family ERV9. Mol Biol Evol. 2000 Feb; 17 (2) :320-30.